Have you noticed the problem ________ he is now in low spirits？________ come?
A．where；WhatB．that；How
C．in which；ForD．what；As
B
that引導(dǎo)同位語(yǔ)從句，用以說(shuō)明problem的內(nèi)容；后面的How come“怎么會(huì)那樣”為固定搭配。
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